USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: COF2_HUMAN USC-OGP 2-DE database:  COF2_HUMAN COF2_HUMAN General information about the entry View entry in simple text format Entry name COF2_HUMAN Primary accession number Q9Y281 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Cofilin-2; AltName: Full=Cofilin, muscle isoform;. Gene name Name=CFL2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1321: pI=5.74; Mw=19265 Cross-references UniProtKB/Swiss-Prot Q9Y281; COF2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name COF2_HUMAN Primary accession number Q9Y281 Secondary accession number(s) G3V5P4 Sequence was last modified on  November 1, 1999 (version 1) Annotations were last modified on  March 15, 2017 (version 166) Name and origin of the protein Description RecName: Full=Cofilin-2; AltName: Full=Cofilin, muscle isoform; Gene name Name=CFL2 Encoded on Name=CFL2 Keywords Acetylation; Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Nemaline myopathy; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AF134802; AAD31280.1; -; mRNA EMBL AF134803; AAD31281.1; -; mRNA EMBL AF283513; AAF97934.1; -; Genomic_DNA EMBL AF242299; AAF64498.1; -; Genomic_DNA EMBL AL355885; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471078; EAW65912.1; -; Genomic_DNA EMBL BC011444; AAH11444.1; -; mRNA EMBL BC022364; AAH22364.1; -; mRNA EMBL BC022876; AAH22876.1; -; mRNA CCDS CCDS58311.1; -. [Q9Y281-3]; . CCDS CCDS9649.1; -. [Q9Y281-1]; . CCDS CCDS9650.1; -. [Q9Y281-1]; . RefSeq NP_001230574.1; NM_001243645.1. [Q9Y281-3]; . RefSeq NP_068733.1; NM_021914.7. [Q9Y281-1]; . RefSeq NP_619579.1; NM_138638.4. [Q9Y281-1]; . RefSeq XP_011534665.1; XM_011536363.2. [Q9Y281-3]; . UniGene Hs.180141; -; . ProteinModelPortal Q9Y281; -; . SMR Q9Y281; -; . BioGrid 107500; 48; . DIP DIP-33178N; -; . IntAct Q9Y281; 27; . MINT MINT-1161448; -; . STRING 9606.ENSP00000298159; -; . iPTMnet Q9Y281; -; . PhosphoSitePlus Q9Y281; -; . SwissPalm Q9Y281; -; . BioMuta CFL2; -; . DMDM 6831517; -; . EPD Q9Y281; -; . PaxDb Q9Y281; -; . PeptideAtlas Q9Y281; -; . PRIDE Q9Y281; -; . TopDownProteomics Q9Y281-1; -. [Q9Y281-1]; . DNASU 1073; -; . Ensembl ENST00000298159; ENSP00000298159; ENSG00000165410. [Q9Y281-1]; . Ensembl ENST00000341223; ENSP00000340635; ENSG00000165410. [Q9Y281-1]; . Ensembl ENST00000555765; ENSP00000452451; ENSG00000165410. [Q9Y281-3]; . Ensembl ENST00000556161; ENSP00000452188; ENSG00000165410. [Q9Y281-3]; . GeneID 1073; -; . KEGG hsa:1073; -; . UCSC uc001wsg.4; human. [Q9Y281-1]; . CTD 1073; -; . DisGeNET 1073; -; . GeneCards CFL2; -; . GeneReviews CFL2; -; . HGNC HGNC:1875; CFL2; . HPA CAB037078; -; . HPA HPA045599; -; . MalaCards CFL2; -; . MIM 601443; gene; . MIM 610687; phenotype; . neXtProt NX_Q9Y281; -; . OpenTargets ENSG00000165410; -; . Orphanet 171436; Typical nemaline myopathy; . PharmGKB PA26424; -; . eggNOG KOG1735; Eukaryota; . eggNOG ENOG41122P5; LUCA; . GeneTree ENSGT00440000033289; -; . HOGENOM HOG000039697; -; . HOVERGEN HBG000381; -; . InParanoid Q9Y281; -; . KO K05765; -; . OMA GLYDATY; -; . OrthoDB EOG091G0PWC; -; . PhylomeDB Q9Y281; -; . TreeFam TF328601; -; . SIGNOR Q9Y281; -; . ChiTaRS CFL2; human; . GeneWiki CFL2_(gene); -; . GenomeRNAi 1073; -; . PRO PR:Q9Y281; -; . Proteomes UP000005640; Chromosome 14; . Bgee ENSG00000165410; -; . CleanEx HS_CFL2; -; . ExpressionAtlas Q9Y281; baseline and differential; . Genevisible Q9Y281; HS; . GO GO:0015629; C:actin cytoskeleton; IEA:InterPro; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0031674; C:I band; IDA:UniProtKB; . GO GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell; . GO GO:0030018; C:Z disc; IDA:UniProtKB; . GO GO:0051015; F:actin filament binding; ISS:UniProtKB; . GO GO:0030042; P:actin filament depolymerization; IDA:UniProtKB; . GO GO:0030043; P:actin filament fragmentation; IEA:Ensembl; . GO GO:0046716; P:muscle cell cellular homeostasis; IEA:Ensembl; . GO GO:0030836; P:positive regulation of actin filament depolymerization; IMP:UniProtKB; . GO GO:0045214; P:sarcomere organization; IEA:Ensembl; . GO GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl; . CDD cd11286; ADF_cofilin_like; 1; . Gene3D 3.40.20.10; -; 1; . InterPro IPR002108; ADF-H; . InterPro IPR029006; ADF-H/Gelsolin-like_dom; . InterPro IPR017904; ADF/Cofilin; . PANTHER PTHR11913; PTHR11913; 1; . Pfam PF00241; Cofilin_ADF; 1; . PRINTS PR00006; COFILIN; . SMART SM00102; ADF; 1; . PROSITE PS51263; ADF_H; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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